ISOBICYPHAT

• CAT Number: T000107
• CAS Number: 51052-72-3
• Molecular Formula: C7H13O4P
• Molecular Weight: 192.151
• Purity: ≥95%
• Synonyms: 1,3-Propanediol, 2-(hydroxymethyl)-2-isopropyl-, cyclic phosphate (1:1)
• Solubility: In alcohol and water
• Storage: Store at room temperature.
• IUPAC Name: 4-propan-2-yl-2,6,7-trioxa-1$l^{5}
• InChI: InChI=1S/C7H13O4P/c1-6(2)7-3-9-12(8,10-4-7)11-5-7/h6H,3-5H2,1-2H3
• InChIKey: CIEZMYRJRCLYNF-UHFFFAOYSA-N
• SMILES: CC(C)C12COP(=O)(OC1)OC2

ISOBICYPHAT(cas 51052-72-3) is a non-competitive GABA antagonist and a potent convulsant by causing epileptoform seizures.

Organophosphorous compound,synthetic
(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.2 nM.
(IC50) for the inhibition of [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 μM; (Ticku M.);
(IC50) for the inhibition of [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes: 480 nM. (Casida J.E.);
experiments with [3H]-labeled GABA-competitive ligands (muscimol, flunitrazepam) showed no influence of Isobicyphat up to 10 μM.

Reference

– Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136

– Cooper et al., Mol. Pharmacol. (1983). 23:207-212

– V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970

– Squires et al., Mol. Pharmacol.(1983) 23:326-331