For research use only. Not for therapeutic Use.
Iruplinalkib（Cat No.:I045105）is an investigational oral tyrosine kinase inhibitor (TKI) targeting anaplastic lymphoma kinase (ALK) and c-ROS oncogene 1 (ROS1), key drivers in various cancers, particularly non-small cell lung cancer (NSCLC). By selectively inhibiting ALK and ROS1 fusion proteins, Iruplinalkib blocks downstream signaling pathways involved in tumor growth and survival. It is designed to overcome resistance mutations and exhibits strong central nervous system (CNS) penetration, addressing brain metastases often seen in ALK-positive patients. Supplied for research in targeted oncology, kinase inhibition, and drug resistance mechanisms in cancer therapy.
| CAS Number | 1854943-32-0 |
| Synonyms | 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)phenyl]pyrimidine-2,4-diamine |
| Molecular Formula | C29H38ClN6O2P |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)phenyl]pyrimidine-2,4-diamine |
| InChI | InChI=1S/C29H38ClN6O2P/c1-35-15-11-29(12-16-35)13-17-36(18-14-29)21-9-10-23(25(19-21)38-2)33-28-31-20-22(30)27(34-28)32-24-7-5-6-8-26(24)39(3,4)37/h5-10,19-20H,11-18H2,1-4H3,(H2,31,32,33,34) |
| InChIKey | ZPCCNHQDFZCULN-UHFFFAOYSA-N |
| SMILES | CN1CCC2(CC1)CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
