For research use only. Not for therapeutic Use.
Irsenontrine (Cat No.: I029511) is a selective 5-HT6 receptor antagonist developed for the treatment of central nervous system disorders, including Alzheimer’s disease and other cognitive impairments. By blocking 5-HT6 receptors, which are primarily expressed in brain regions involved in learning and memory, irsenontrine enhances the release of neurotransmitters such as acetylcholine and glutamate. This modulation improves cognitive function and synaptic plasticity. Irsenontrine is being explored in clinical trials as a potential therapy for dementia-related conditions and cognitive dysfunction.
| CAS Number | 1429509-82-9 |
| Synonyms | 7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-[(3S)-oxolan-3-yl]-5H-pyrazolo[4,3-c]quinolin-4-one |
| Molecular Formula | C22H22N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H22N4O3/c1-12-9-23-22(28-3)13(2)19(12)14-4-5-16-18(8-14)25-21(27)17-10-24-26(20(16)17)15-6-7-29-11-15/h4-5,8-10,15H,6-7,11H2,1-3H3,(H,25,27)/t15-/m0/s1 |
| InChIKey | CKJDCNZBABIEBZ-HNNXBMFYSA-N |
| SMILES | CC1=CN=C(C(=C1C2=CC3=C(C=C2)C4=C(C=NN4C5CCOC5)C(=O)N3)C)OC |
| Reference | [1]. Miyamoto, et al. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine. WO2018221550 A1 [2]. Hershey LA, et al. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019;36(4):309-319. [3]. Eisai to present latest research on Alzheimer’s disease / dementia pipeline at the 14th international conference on Alzheimer’s & Parkinson’s diseases |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
