IRE1-IN-VII

• CAT Number: I012551
• CAS Number: 20035-41-0
• Molecular Formula: C8H7BrO3
• Molecular Weight: 231.045
• Purity: ≥95%
• Synonyms: 3-Methoxy-6-bromosalicylaldehyde; 6-Bromo-3-methoxysalicylaldehyde
• Target: IRE1
• InChI: InChI=1S/C8H7BrO3/c1-12-7-3-2-6(9)5(4-10)8(7)11/h2-4,11H,1H3
• InChIKey: JUPJZUTYDWXZAQ-UHFFFAOYSA-N
• SMILES: COC1=C(C(=C(C=C1)Br)C=O)O

IRE1-IN-VII (CAT: I012551) is an inhibitor of the endoribonuclease activity of IRE1 (inositol-requiring enzyme 1), a key component of the unfolded protein response (UPR) pathway. It has been shown to strongly inhibit the splicing of XBP-1 (X-box binding protein 1), a downstream target of IRE1, in cellular models of acute endoplasmic reticulum (ER) stress. By inhibiting IRE1 activity, IRE1-IN-VII can modulate the UPR pathway and potentially attenuate the cellular response to ER stress.