IRAK-4 protein kinase inhibitor 2

• CAT Number: I045036
• CAS Number: 301675-24-1
• Molecular Formula: C14H10N4O3
• Molecular Weight: 282.25
• Purity: ≥95%
• Synonyms: N-(1H-benzimidazol-2-yl)-3-nitrobenzamide
• InChI: InChI=1S/C14H10N4O3/c19-13(9-4-3-5-10(8-9)18(20)21)17-14-15-11-6-1-2-7-12(11)16-14/h1-8H,(H2,15,16,17,19)
• InChIKey: QPKROMNIEAEFQA-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)NC(=N2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-]

IRAK-4 Protein Kinase Inhibitor 2（Cat No.:I045036）is a selective small-molecule inhibitor targeting interleukin-1 receptor-associated kinase 4 (IRAK-4), a critical mediator in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. By blocking IRAK-4 activity, this compound suppresses downstream NF-κB and MAPK activation, reducing pro-inflammatory cytokine production. It is widely studied for its therapeutic potential in autoimmune and inflammatory diseases, such as rheumatoid arthritis and lupus. IRAK-4 Inhibitor 2 is also valuable in cancer immunotherapy research, offering insights into immune modulation and inflammation-driven tumor progression. Suitable for biochemical and cellular studies.