IPR-803

• CAT Number: I017989
• CAS Number: 892243-35-5
• Molecular Formula: C27H23N3O4
• Molecular Weight: 453.49
• Purity: ≥95%
• Synonyms: 3-[[12-(azepan-1-yl)-8-oxo-15-oxa-14-azatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,4,6,9,11,13-heptaen-10-yl]amino]benzoic acid
• InChI: InChI=1S/C27H23N3O4/c31-25-18-10-3-4-11-19(18)26-23-22(25)20(28-17-9-7-8-16(14-17)27(32)33)15-21(24(23)29-34-26)30-12-5-1-2-6-13-30/h3-4,7-11,14-15,28H,1-2,5-6,12-13H2,(H,32,33)
• InChIKey: UAEULQWANHYLGJ-UHFFFAOYSA-N
• SMILES: C1CCCN(CC1)C2=CC(=C3C4=C(C5=CC=CC=C5C3=O)ON=C24)NC6=CC=CC(=C6)C(=O)O

IPR-803（Cat No.:I017989）is a small-molecule inhibitor that disrupts the interaction between Nrf2 (nuclear factor erythroid 2–related factor 2) and its negative regulator Keap1. By blocking Keap1, IPR-803 stabilizes Nrf2, leading to enhanced transcription of antioxidant response element (ARE)-driven genes. This activation boosts cellular defense mechanisms against oxidative stress and electrophilic damage. IPR-803 is widely used in research exploring oxidative stress–related diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. As a chemical probe, it provides valuable insights into the therapeutic potential of targeting the Keap1–Nrf2 signaling pathway.