For research use only. Not for therapeutic Use.
IPN60090 dihydrochloride（Cat No.:I014833）is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), a critical regulator of necroptosis, apoptosis, and inflammatory signaling. By blocking RIPK1 activity, it prevents programmed necrotic cell death and the release of pro-inflammatory mediators, offering therapeutic potential in neurodegenerative diseases, autoimmune disorders, and inflammatory pathologies. The dihydrochloride salt enhances solubility and experimental utility. IPN60090 dihydrochloride is a valuable research tool for investigating cell death pathways, inflammation regulation, and the development of targeted therapies aimed at RIPK1-driven disease mechanisms.
| CAS Number | 2102101-72-2 |
| Synonyms | 1-[(2R)-4-[6-[[2-[4-(3,3-difluorocyclobutyl)oxy-6-methylpyridin-2-yl]acetyl]amino]pyridazin-3-yl]-2-fluorobutyl]-N-methyltriazole-4-carboxamide;dihydrochloride |
| Molecular Formula | C24H29Cl2F3N8O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[(2R)-4-[6-[[2-[4-(3,3-difluorocyclobutyl)oxy-6-methylpyridin-2-yl]acetyl]amino]pyridazin-3-yl]-2-fluorobutyl]-N-methyltriazole-4-carboxamide;dihydrochloride |
| InChI | InChI=1S/C24H27F3N8O3.2ClH/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2;;/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36);2*1H/t15-;;/m1../s1 |
| InChIKey | MREGZVYRKYDENT-QCUBGVIVSA-N |
| SMILES | CC1=CC(=CC(=N1)CC(=O)NC2=NN=C(C=C2)CC[C@H](CN3C=C(N=N3)C(=O)NC)F)OC4CC(C4)(F)F.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
