For research use only. Not for therapeutic Use.
IPI-9119(Cat No.:I014804)is a potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan catabolism that enables tumor immune evasion. By blocking IDO1, IPI-9119 helps restore T-cell activity and enhances antitumor immune responses. Preclinical models demonstrate strong efficacy in reducing tumor growth and synergizing with checkpoint inhibitors. Its specificity minimizes off-target effects, making it a valuable candidate for immuno-oncology research. IPI-9119 provides a powerful tool for exploring IDO1 biology, immune checkpoint modulation, and novel therapeutic strategies in cancer immunotherapy.
CAS Number | 1346564-56-4 |
Synonyms | 4-[[4-(2,6-difluorophenyl)-5-oxotetrazole-1-carbonyl]-propan-2-ylamino]-3-phenoxybenzoic acid |
Molecular Formula | C24H19F2N5O5 |
Purity | ≥95% |
IUPAC Name | 4-[[4-(2,6-difluorophenyl)-5-oxotetrazole-1-carbonyl]-propan-2-ylamino]-3-phenoxybenzoic acid |
InChI | InChI=1S/C24H19F2N5O5/c1-14(2)29(19-12-11-15(22(32)33)13-20(19)36-16-7-4-3-5-8-16)23(34)31-24(35)30(27-28-31)21-17(25)9-6-10-18(21)26/h3-14H,1-2H3,(H,32,33) |
InChIKey | VYXOFKWKPKVNID-UHFFFAOYSA-N |
SMILES | CC(C)N(C1=C(C=C(C=C1)C(=O)O)OC2=CC=CC=C2)C(=O)N3C(=O)N(N=N3)C4=C(C=CC=C4F)F |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |