For research use only. Not for therapeutic Use.
Ipatasertib-NH2（Cat No.:I015517）is a functionalized derivative of ipatasertib, a potent, selective small-molecule inhibitor of serine/threonine kinase AKT (protein kinase B). The modification introduces an amino group, enabling conjugation to linkers or probes for advanced applications such as PROTAC development, chemical biology, or drug delivery studies. Like ipatasertib, it disrupts AKT-mediated signaling pathways controlling cell growth, metabolism, and survival, which are frequently dysregulated in cancers. Ipatasertib-NH2 serves as a versatile tool for oncology research, signal transduction studies, and the design of next-generation targeted therapeutics.
| CAS Number | 1001382-14-4 |
| Synonyms | (2S)-3-amino-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one |
| Molecular Formula | C21H26ClN5O2 |
| Purity | ≥95% |
| IUPAC Name | (2S)-3-amino-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one |
| InChI | InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5,12-13,16-17,28H,6-11,23H2,1H3/t13-,16-,17-/m1/s1 |
| InChIKey | FKWGZLUCQAOQDJ-KBRIMQKVSA-N |
| SMILES | C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CN)C4=CC=C(C=C4)Cl)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
