IP7e

• CAT Number: I011274
• CAS Number: 500164-74-9
• Molecular Formula: C23H22N2O4
• Molecular Weight: 390.43
• Purity: ≥95%
• Synonyms: 6-[4-(2-methoxyethoxymethyl)phenyl]-5-methyl-3-phenyl-[1,2]oxazolo[4,5-c]pyridin-4-one
• InChI: InChI=1S/C23H22N2O4/c1-25-19(17-10-8-16(9-11-17)15-28-13-12-27-2)14-20-21(23(25)26)22(24-29-20)18-6-4-3-5-7-18/h3-11,14H,12-13,15H2,1-2H3
• InChIKey: YCAACZFPADQMAR-UHFFFAOYSA-N
• SMILES: CN1C(=CC2=C(C1=O)C(=NO2)C3=CC=CC=C3)C4=CC=C(C=C4)COCCOC

IP7e (Cat No.: I011274) is a selective small-molecule inhibitor of casein kinase 1 (CK1), a serine/threonine kinase involved in circadian rhythm regulation, Wnt signaling, and various cellular processes. By blocking CK1 activity, IP7e is used to study kinase-mediated control of cell cycle progression, signal transduction, and transcriptional regulation. Researchers apply it in preclinical models to explore therapeutic approaches for cancer, neurodegeneration, and sleep disorders. Although not developed for clinical use, IP7e provides a valuable pharmacological probe for investigating CK1-dependent biological mechanisms.

Reference

[1]. Samuel Hintermann, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17(1):193-6.
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[2]. Francesca Montarolo, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9(9):e108791.
[Content Brief]