INDY

• CAT Number: R031459
• CAS Number: 1169755-45-6
• Molecular Formula: C12H13NO2S
• Molecular Weight: 235.30
• Purity: ≥95%
• Synonyms: (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
• InChI: InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6-
• InChIKey: GCSZJMUFYOAHFY-SDQBBNPISA-N
• SMILES: CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C

INDY(CAT: R031459) is a potent, ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC₅₀ values of 0.24 μM and 0.23 μM, respectively. By binding within the ATP pocket (Ki = 0.18 μM), INDY disrupts kinase activity and reduces the self-renewal capacity of both glioblastoma and neural progenitor cells. In cellular assays, it attenuates tau phosphorylation in a dose-dependent manner, effectively reversing Dyrk1A-driven aberrant signaling. INDY also rescues NFAT pathway suppression and demonstrates developmental restoration in Xenopus embryo models via its prodrug form, ProINDY. This compound is a valuable research tool in oncology, neurodegeneration, and kinase signaling studies.