Indolelactic acid-d5

• CAT Number: I045600
• CAS Number: 2470130-19-7
• Molecular Formula: C11H6D5NO3
• Molecular Weight: 210.24
• Purity: ≥95%
• Synonyms: 2-hydroxy-3-(2,4,5,6,7-pentadeuterio-1H-indol-3-yl)propanoic acid
• InChI: InChI=1S/C11H11NO3/c13-10(11(14)15)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,10,12-13H,5H2,(H,14,15)/i1D,2D,3D,4D,6D
• InChIKey: XGILAAMKEQUXLS-SNOLXCFTSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)O

Indolelactic acid-d5 (Cat No.: I045600) is a stable isotope-labeled analog of indole-3-lactic acid, a tryptophan-derived microbial metabolite produced in the gut. Incorporating five deuterium atoms, it is primarily used as an internal standard in liquid chromatography–mass spectrometry (LC-MS/MS) for accurate quantification in biological samples. Indolelactic acid plays an important role in host–microbiome interactions, immune regulation, and intestinal health. Indolelactic acid-d5 is a valuable tool for metabolomics, microbiome studies, and biomarker discovery, enabling precise investigation of tryptophan metabolism and indole derivative pathways.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[Content Brief]

[2]. Francisco García-Tabares, et al. Production of 3-indoleacetic acid and 3-indolelactic acid in Azotobacter vinelandii cultures supplemented with tryptophan. Appl Microbiol Biotechnol.1987 Mar, 25 (6):502–506.