INCB38579

• CAT Number: I042975
• CAS Number: 1246207-65-7
• Molecular Formula: C25H34N6O
• Molecular Weight: 434.58
• Purity: ≥95%
• Synonyms: 1-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydro-1H-isoquinolin-2-yl]-2-cyclopentylethanone
• InChI: InChI=1S/C25H34N6O/c1-29-10-12-30(13-11-29)23-16-22(27-25(26)28-23)20-7-6-19-8-9-31(17-21(19)15-20)24(32)14-18-4-2-3-5-18/h6-7,15-16,18H,2-5,8-14,17H2,1H3,(H2,26,27,28)
• InChIKey: LZOCXAJJOQPLKB-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC4=C(CCN(C4)C(=O)CC5CCCC5)C=C3)N

INCB38579（Cat No.:I042975）is a selective inhibitor of Janus kinase 1 (JAK1), a key enzyme in the JAK-STAT signaling pathway, which regulates immune response and cell growth. By targeting JAK1, INCB38579 aims to modulate inflammatory and immune responses, making it a potential therapeutic for autoimmune diseases and inflammatory conditions, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It may also have applications in certain cancers, where aberrant JAK1 activity contributes to tumor growth. Ongoing clinical trials are evaluating its safety, efficacy, and potential in treating various immune-related disorders and cancers.