For research use only. Not for therapeutic Use.
Inaxaplin (Cat No.: I029298) is an investigational, oral small-molecule inhibitor of APOL1 protein function, developed by Vertex Pharmaceuticals for the treatment of APOL1-mediated kidney diseases, such as focal segmental glomerulosclerosis (FSGS). APOL1 genetic variants are associated with increased risk of progressive kidney disease, particularly in individuals of African ancestry. Inaxaplin targets the underlying genetic cause by inhibiting APOL1-induced toxicity in kidney cells, thereby reducing proteinuria and preserving kidney function. It represents a precision medicine approach currently being evaluated in clinical trials.
| CAS Number | 2446816-88-0 |
| Synonyms | 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide |
| Molecular Formula | C21H18F3N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H18F3N3O3/c22-11-3-1-10(2-4-11)18-13(14-7-12(23)8-15(24)19(14)27-18)5-6-17(29)26-20-16(28)9-25-21(20)30/h1-4,7-8,16,20,27-28H,5-6,9H2,(H,25,30)(H,26,29)/t16-,20+/m1/s1 |
| InChIKey | CTXLPYZCBOVVQK-UZLBHIALSA-N |
| SMILES | C1C(C(C(=O)N1)NC(=O)CCC2=C(NC3=C2C=C(C=C3F)F)C4=CC=C(C=C4)F)O |
| Reference | [1]. WO2020131807 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
