IN-1130

• CAT Number: I007291
• CAS Number: 868612-83-3
• Molecular Formula: C25H20N6O
• Molecular Weight: 420.47
• Purity: ≥95%
• Synonyms: 3-[[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]methyl]benzamide
• InChI: InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
• InChIKey: RYKSGWSKILPDDY-UHFFFAOYSA-N
• SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)CC3=CC(=CC=C3)C(=O)N)C4=CC5=NC=CN=C5C=C4

IN-1130（Cat No.:I007291）is a small-molecule inhibitor targeting activin receptor-like kinase 5 (ALK5), a type I receptor in the TGF-β signaling pathway. By blocking ALK5 activity, IN-1130 interferes with Smad2/3 phosphorylation, thereby suppressing profibrotic and proinflammatory signaling. This makes it a valuable research compound for studying fibrotic diseases, cancer progression, and immune regulation. Preclinical studies have shown its potential in reducing tissue fibrosis and tumor growth. IN-1130 is widely used in biomedical research to explore therapeutic strategies for TGF-β–driven disorders and pathological tissue remodeling.