IMD-0354 - CAS 978-62-1
IMD-0354 is a synthetic selective NF-kB inhibitor.
in vitro: IMD-0354 inhibits p65 translocation to the nucleus promoted by FGF2 in PASMCs. Furthermore, the time courses of Erk1/2, MCP-1, and PAI-1 stimulated with FGF2 are each markedly shortened by IMD-0354. IMD-0354 suppresses proliferation and induced apoptosis of PASMCs. IMD-0354 decreases FGF2, PAI-1, t-PA mRNA expressions. IMD-0354 also inhibits the translocation of NF-kB subunit p65 into the nucleus.
in vivo: IMD-0354 has potential as a new therapeutic tool for PAH. IMD-0354 improves survival in the PAH rats. IMD-0354 improves physical signs of RVH in the PAH rats. IMD-0354 also decreases medial hypertrophy in the pulmonary arterioles.
Catalog Number: I005720
CAS Number: 978-62-1
PubChem Substance ID:355038352
Molecular Formula: C15H8ClF6NO2
Molecular Weight:383.7
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | IMD0354;IMD 0354; |
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Property
Molecular Formula: | C15H8ClF6NO2 |
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Molecular Weight | 383.7 |
Target: | IκB/IKK |
Solubility | 10 mM in DMSO |
Purity | ≥95% |
Storage | 3 years -20C powder |
Computed Descriptor
InChI | InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) |
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InChIKey | CHILCFMQWMQVAL-UHFFFAOYSA-N |
SMILES | O=C(C1=C(O)C=CC(Cl)=C1)NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2 |