For research use only. Not for therapeutic Use.
IL-17A modulator-2（Cat No.:I045134）is an investigational small-molecule compound developed to selectively inhibit interleukin-17A (IL-17A) signaling, a key driver of inflammation in autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis. By disrupting the interaction between IL-17A and its receptor, this modulator reduces downstream activation of pro-inflammatory pathways, including NF-κB and MAPK signaling. IL-17A modulator-2 offers a potential oral alternative to monoclonal antibodies, with improved patient convenience and tissue penetration. Supplied for research into cytokine modulation, autoimmune therapeutics, and the development of small-molecule anti-inflammatory agents.
| CAS Number | 2748749-47-3 |
| Synonyms | N-[(2S)-1-[[4-(1-hydroxy-3,5-dimethoxypyridin-4-ylidene)cyclohexa-2,5-dien-1-ylidene]amino]-1-oxo-3,3-diphenylpropan-2-yl]-2-methylpyrazole-3-carboxamide |
| Molecular Formula | C33H31N5O5 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S)-1-[[4-(1-hydroxy-3,5-dimethoxypyridin-4-ylidene)cyclohexa-2,5-dien-1-ylidene]amino]-1-oxo-3,3-diphenylpropan-2-yl]-2-methylpyrazole-3-carboxamide |
| InChI | InChI=1S/C33H31N5O5/c1-37-26(18-19-34-37)32(39)36-31(29(22-10-6-4-7-11-22)23-12-8-5-9-13-23)33(40)35-25-16-14-24(15-17-25)30-27(42-2)20-38(41)21-28(30)43-3/h4-21,29,31,41H,1-3H3,(H,36,39)/t31-/m0/s1 |
| InChIKey | MZLXJJWREASCOJ-HKBQPEDESA-N |
| SMILES | CN1C(=CC=N1)C(=O)N[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)N=C4C=CC(=C5C(=CN(C=C5OC)O)OC)C=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
