IK1 inhibitor PA-6

• CAT Number: I018181
• CAS Number: 500715-03-7
• Molecular Formula: C31H32N4O2
• Molecular Weight: 492.61
• Purity: ≥95%
• Synonyms: N’-[4-[5-[4-[[amino(phenyl)methylidene]amino]phenoxy]pentoxy]phenyl]benzenecarboximidamide
• IUPAC Name: N'-[4-[5-[4-[[amino(phenyl)methylidene]amino]phenoxy]pentoxy]phenyl]benzenecarboximidamide
• InChI: InChI=1S/C31H32N4O2/c32-30(24-10-4-1-5-11-24)34-26-14-18-28(19-15-26)36-22-8-3-9-23-37-29-20-16-27(17-21-29)35-31(33)25-12-6-2-7-13-25/h1-2,4-7,10-21H,3,8-9,22-23H2,(H2,32,34)(H2,33,35)
• InChIKey: PETGITKEGWIZEL-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(=NC2=CC=C(C=C2)OCCCCCOC3=CC=C(C=C3)N=C(C4=CC=CC=C4)N)N

PA-6（Cat No.:I018181）is a potent and selective inhibitor of the inward rectifier potassium current (IK1), mediated by Kir2.x channels. By blocking IK1, PA-6 prolongs cardiac action potential duration and reduces repolarization reserve, making it a valuable tool for studying arrhythmogenesis and electrophysiological remodeling. It is particularly useful in cardiovascular disease research, including atrial fibrillation and ventricular arrhythmia models. PA-6 enables researchers to dissect the role of IK1 in cardiac excitability and ion channel regulation, supporting drug discovery efforts in cardiac electrophysiology and therapeutic intervention development.