iHCK-37

• CAT Number: I044445
• CAS Number: 516478-09-4
• Molecular Formula: C30H32N4O2S2
• Molecular Weight: 544.73
• Purity: ≥95%
• Synonyms: N-(2-morpholin-4-ylphenyl)-2-[[2-(2-phenylethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]acetamide
• InChI: InChI=1S/C30H32N4O2S2/c35-27(31-23-11-5-6-12-24(23)34-16-18-36-19-17-34)20-37-29-28-22-10-4-7-13-25(22)38-30(28)33-26(32-29)15-14-21-8-2-1-3-9-21/h1-3,5-6,8-9,11-12H,4,7,10,13-20H2,(H,31,35)
• InChIKey: YBVMBFMOYYGDEM-UHFFFAOYSA-N
• SMILES: C1CCC2=C(C1)C3=C(S2)N=C(N=C3SCC(=O)NC4=CC=CC=C4N5CCOCC5)CCC6=CC=CC=C6

iHCK-37（Cat No.:I044445）is a potent and selective inhibitor of hematopoietic cell kinase (HCK), a member of the Src family of tyrosine kinases primarily expressed in myeloid cells. HCK plays a key role in regulating immune cell activation, inflammatory signaling, and oncogenic processes in hematological malignancies. By targeting HCK, iHCK-37 suppresses downstream signaling pathways such as STAT3 and NF-κB, reducing cytokine production and cell proliferation. It is particularly useful in preclinical research focused on leukemia, lymphoma, and inflammatory disorders. iHCK-37 supports the exploration of targeted therapies involving Src-family kinase modulation.