For research use only. Not for therapeutic Use.
IGUANA-1 (Cat No.: I042464) is a small-molecule inhibitor designed to target the Sonic Hedgehog (Shh) signaling pathway by antagonizing Smoothened (SMO), a key transmembrane protein in the pathway. By blocking SMO, IGUANA-1 suppresses downstream transcriptional activation of GLI proteins, thereby inhibiting cellular proliferation and differentiation processes regulated by Shh signaling. This compound is valuable in developmental biology and cancer research, particularly in studying basal cell carcinoma and medulloblastoma, where aberrant Shh activity drives tumor growth. IGUANA-1 aids in exploring therapeutic strategies against Shh-dependent malignancies.
| CAS Number | 2756014-25-0 |
| Synonyms | 3-(4-chloro-2-methoxyphenyl)-1-[4-(2-methoxyphenyl)phenyl]-6,7-dihydro-5H-imidazo[1,2-a]pyrimidine;formic acid |
| Molecular Formula | C27H26ClN3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H24ClN3O2.CH2O2/c1-31-24-7-4-3-6-21(24)18-8-11-20(12-9-18)30-17-23(29-15-5-14-28-26(29)30)22-13-10-19(27)16-25(22)32-2;2-1-3/h3-4,6-13,16-17H,5,14-15H2,1-2H3;1H,(H,2,3) |
| InChIKey | GONSQPFNQHUNGK-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1C2=CC=C(C=C2)N3C=C(N4C3=NCCC4)C5=C(C=C(C=C5)Cl)OC.C(=O)O |
| Reference | [1]. Feng Z, et al. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol. 2022 Oct;18(10):1065-1075. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
