IGS-1.76

• CAT Number: I045522
• CAS Number: 313480-47-6
• Molecular Formula: C22H18N2OS
• Molecular Weight: 358.46
• Purity: ≥95%
• Synonyms: N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
• InChI: InChI=1S/C22H18N2OS/c25-21(24-22-23-19-13-7-8-14-20(19)26-22)15-18(16-9-3-1-4-10-16)17-11-5-2-6-12-17/h1-14,18H,15H2,(H,23,24,25)
• InChIKey: GYQWKTIZRYVFEM-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(CC(=O)NC2=NC3=CC=CC=C3S2)C4=CC=CC=C4

IGS-1.76 (Cat No.: I045522) is a selective small-molecule inhibitor of interferon-stimulated gene 15 (ISG15) conjugation, a ubiquitin-like modification involved in antiviral defense and immune regulation. By blocking ISGylation, IGS-1.76 modulates pathways governing protein stability, innate immunity, and host–pathogen interactions. Researchers employ this compound to study antiviral signaling, immune evasion by pathogens, and the role of ISG15 in cancer biology. Its specificity makes it a valuable tool for dissecting post-translational modifications and exploring therapeutic strategies targeting immune regulation, viral infection, and tumor progression.

Reference

[1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14
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