For research use only. Not for therapeutic Use.
iGOT1-01（Cat No.:I029213）is a selective small-molecule inhibitor targeting glutamic-oxaloacetic transaminase 1 (GOT1), a key enzyme in the malate–aspartate shuttle that supports cellular redox balance and metabolic flux. By inhibiting GOT1, iGOT1-01 disrupts aspartate biosynthesis and NAD⁺ regeneration, impairing tumor cell proliferation, particularly in cancers reliant on glutamine metabolism such as pancreatic ductal adenocarcinoma (PDAC). Preclinical studies have shown that iGOT1-01 induces metabolic stress and sensitizes tumors to oxidative damage. Its metabolic specificity makes it a promising tool for exploring cancer metabolism and developing targeted therapies against glutamine-dependent malignancies.
| CAS Number | 882256-55-5 |
| Synonyms | 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide |
| Molecular Formula | C19H20N4O |
| Purity | ≥95% |
| IUPAC Name | 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide |
| InChI | InChI=1S/C19H20N4O/c24-19(21-15-5-2-1-3-6-15)23-13-11-22(12-14-23)18-8-4-7-17-16(18)9-10-20-17/h1-10,20H,11-14H2,(H,21,24) |
| InChIKey | MGSDOEMLWKEWSV-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C2=CC=CC3=C2C=CN3)C(=O)NC4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
