IGF-1R inhibitor-2

• CAT Number: I045178
• CAS Number: 1116236-15-7
• Molecular Formula: C24H24FN7O2
• Molecular Weight: 461.49
• Purity: ≥95%
• Synonyms: 2-fluoro-6-[[2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide
• InChI: InChI=1S/C24H24FN7O2/c1-32-9-7-13-11-19(34-2)18(10-14(13)12-32)29-24-30-22-15(6-8-27-22)23(31-24)28-17-5-3-4-16(25)20(17)21(26)33/h3-6,8,10-11H,7,9,12H2,1-2H3,(H2,26,33)(H3,27,28,29,30,31)
• InChIKey: FDCFRUWNFPYFBR-UHFFFAOYSA-N
• SMILES: CN1CCC2=CC(=C(C=C2C1)NC3=NC4=C(C=CN4)C(=N3)NC5=C(C(=CC=C5)F)C(=O)N)OC

IGF-1R inhibitor-2（Cat No.:I045178）is a potent and selective blocker of the insulin-like growth factor 1 receptor (IGF-1R), a tyrosine kinase that regulates cell growth, survival, and metabolism. By inhibiting IGF-1R signaling, it suppresses downstream PI3K/AKT and MAPK pathways, reducing proliferation and promoting apoptosis in cancer cells. IGF-1R inhibitor-2 shows strong activity in tumor models driven by IGF-1/IGF-2 overexpression or pathway dysregulation. It is a valuable research tool for studying growth factor signaling and holds therapeutic potential in oncology, metabolic disorders, and other IGF-1R–related diseases.