IEM-1460

• CAT Number: I010436
• CAS Number: 121034-89-7
• Molecular Formula: C19H38Br2N2
• Molecular Weight: 454.33
• Purity: ≥95%
• Synonyms: 5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide
• InChI: InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1
• InChIKey: CQTDZUSQSTUZDA-UHFFFAOYSA-M
• SMILES: C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

IEM-1460（Cat No.:I010436）is a synthetic, voltage-dependent open-channel blocker that selectively targets calcium-permeable AMPA receptors lacking the GluA2 subunit. It exhibits high potency, with an IC₅₀ of 2.6 μM for GluA2-lacking receptors, compared to 1102 μM for GluA2-containing receptors . Additionally, IEM-1460 blocks NMDA receptor-mediated currents and has demonstrated anticonvulsant effects in vivo . Its selectivity makes it a valuable tool for studying excitatory neurotransmission and neuronal circuit dynamics in neuroscience research.