Idoxifene

• CAT Number: R045580
• CAS Number: 116057-75-1
• Molecular Formula: C28H30INO
• Molecular Weight: 523.45
• Purity: ≥95%
• Synonyms: 1-[2-[4-[(E)-1-(4-iodophenyl)-2-phenylbut-1-enyl]phenoxy]ethyl]pyrrolidine
• InChI: InChI=1S/C28H30INO/c1-2-27(22-8-4-3-5-9-22)28(23-10-14-25(29)15-11-23)24-12-16-26(17-13-24)31-21-20-30-18-6-7-19-30/h3-5,8-17H,2,6-7,18-21H2,1H3/b28-27-
• InChIKey: JJKOTMDDZAJTGQ-DQSJHHFOSA-N
• SMILES: CC/C(=C(/C1=CC=C(C=C1)OCCN2CCCC2)\C3=CC=C(C=C3)I)/C4=CC=CC=C4

Idoxifene（Cat No.:R045580）is a nonsteroidal selective estrogen receptor modulator (SERM) structurally related to tamoxifen. It was developed for the treatment and prevention of hormone-responsive breast cancer and osteoporosis. Idoxifene exhibits both estrogen agonist and antagonist activities, depending on the target tissue. Its iodine substitution enhances receptor binding affinity and metabolic stability. Though it showed promise in early clinical trials, development was discontinued due to insufficient efficacy compared to existing therapies. Despite this, idoxifene remains of interest in research exploring estrogen receptor pharmacology and SERM design for cancer and endocrine disorders.

Reference

[1]. Zhou YJ, et al. Inhibitory effects of idoxifene on hepatic fibrosis in rats. Acta Pharmacol Sin. 2005 May;26(5):581-6.
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[2]. Lu G, et al. Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats. Life Sci. 2004 Jan 2;74(7):897-907.
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