For research use only. Not for therapeutic Use.
ICA-27243(CAT: I007250) is a selective, potent, and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM, showing reduced activity at KCNQ4 and KCNQ3/Q5. In SH-SY5Y neuroblastoma cells, it induces membrane hyperpolarization, reversible by M-current inhibitors XE-991 and linopirdine. ICA-27243 enhances 86Rb⁺ efflux (EC50 = 0.2 μM) and increases whole-cell currents in CHO cells expressing KCNQ2/Q3 channels (EC50 = 0.4 μM), producing a hyperpolarizing V1/2 shift of –19 mV at 10 μM. Orally administered in mice, ICA-27243 displays anticonvulsant activity in the maximal electroshock model (ED50 = 8.4 mg/kg), supporting its potential in epilepsy research.
| CAS Number | 325457-89-4 |
| Synonyms | N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide |
| Molecular Formula | C12H7ClF2N2O |
| Purity | ≥95% |
| IUPAC Name | N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide |
| InChI | InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18) |
| InChIKey | GDGUOCFTHNGPBK-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C(=O)NC2=CN=C(C=C2)Cl)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
