ICA-105665（Cat No.:I045898）is an investigational small-molecule drug that functions as a selective activator of Kv7 (KCNQ) potassium channels, which play a key role in regulating neuronal excitability. By enhancing M-current, ICA-105665 stabilizes membrane potential and reduces hyperexcitability, making it a candidate for treating epilepsy and other neurological disorders. Preclinical and early clinical studies have demonstrated its potential to suppress seizures without strong sedative effects. ICA-105665 serves as a valuable tool for exploring ion channel pharmacology, neuronal signaling, and therapeutic development aimed at hyperexcitability-related conditions such as epilepsy and pain.