iBRD4-BD1

• CAT Number: I042604
• CAS Number: 2839318-17-9
• Molecular Formula: C29H30F3N5O
• Molecular Weight: 521.58
• Purity: ≥95%
• Synonyms: 2-(2-methyl-5-propan-2-ylphenoxy)-4-[3-piperidin-4-yl-5-[4-(trifluoromethyl)phenyl]imidazol-4-yl]pyrimidine
• InChI: InChI=1S/C29H30F3N5O/c1-18(2)21-5-4-19(3)25(16-21)38-28-34-15-12-24(36-28)27-26(20-6-8-22(9-7-20)29(30,31)32)35-17-37(27)23-10-13-33-14-11-23/h4-9,12,15-18,23,33H,10-11,13-14H2,1-3H3
• InChIKey: ULDFEUPLPPWJDA-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(C)C)OC2=NC=CC(=N2)C3=C(N=CN3C4CCNCC4)C5=CC=C(C=C5)C(F)(F)F

iBRD4-BD1 (Cat No.: I042604) is a selective small-molecule inhibitor that targets the first bromodomain (BD1) of BRD4, a member of the BET (bromodomain and extra-terminal) protein family involved in regulating gene transcription through recognition of acetylated lysines on histones. By specifically inhibiting BRD4-BD1, iBRD4-BD1 disrupts the transcription of oncogenes such as MYC, making it a valuable tool in cancer research. Its high selectivity enables detailed studies of BD1-specific functions, aiding in the development of targeted epigenetic therapies with reduced off-target effects.

Reference

[1]. Anand Divakaran, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627.
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