CONTACT US
Home > Reference Standards> > Iberiotoxin
Iberiotoxin

Iberiotoxin

  • CAT Number: R014712
  • CAS Number: 129203-60-7
  • Molecular Formula: C179H274N50O55S7
  • Molecular Weight: 4230.876
  • Purity: ≥95%
Inquiry Now

<p>It is a highly selective blocker of the high conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel. <strong>Iberiotoxin </strong>appears to modulate <strong>ChTX </strong>binding by an allosteric mechanism.</p><br />37-amino acid peptide with 3 disulfide bridges.<!–C<SUB>179</SUB>H<SUB>274</SUB>N<SUB>50</SUB>O<SUB>55</SUB>S<SUB>7</SUB>–>Synthetic, originally from <I>Buthus tamulus</I> scorpion venom.</br><p>As a specific blocker of Ca<sup>2+</sup>-activated K<sup>+</sup> channels, <strong>Iberiotoxin </strong>does not affect other types of voltage-dependent K<sup>+</sup> channels which are sensitive to inhibition by <strong>Charybdotoxin</strong>. <strong>Iberiotoxin </strong>blocks Ca<sup>2+</sup>-activated K<sup>+</sup> channels by binding to their external mouth, and this binding is tighter and with an equilibrium dissociation constant 10-fold lower than that of <strong>Charybdotoxin</strong>.</p></br>

Catalog Number R014712
CAS Number 129203-60-7
Molecular Formula

C179H274N50O55S7

Purity 95%
Target Potassium Channel
Solubility Soluble to 0.70 mg/ml in sterile water
Storage Desiccate at -20C
InChI InChI=1S/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)
InChIKey VDNVVLOBNHIMQA-UHFFFAOYSA-N
SMILES CC(C)CC1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)O)CCCCN)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)CCC(=O)O)CCCCN)CO)C(C)C)CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCC(=O)N6)C(=O)NC(CCSC)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC7CSSCC(NC(=O)C(NC7=O)CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)NC(CCC(=O)N)C(=O)O)CCCCN)CCCNC(=N)N)CC(=O)O)C(C)C)CC9=CC=CC=C9
Reference

– Galvez et al., /Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus./<I> J. Biol. Chem. </I> (1990) 265(19):11083-11090<br /><br />- Candia et al., /Mode of action of Iberiotoxin, a potent blocker of the large conductance Ca2+-activated K+ channel./ Biophys. J. (1992). 63:583-590<br /><br /><br /><br />

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!