IACS-8803 disodium

• CAT Number: I045480
• CAS Number: 2243079-36-7
• Molecular Formula: C20H23FN10Na2O9P2S2
• Molecular Weight: 738.51
• Purity: ≥95%

IACS-8803 disodium (Cat No.: I045480) is a potent mitochondrial complex I (NADH:ubiquinone oxidoreductase) inhibitor that blocks oxidative phosphorylation, reducing ATP production and inducing metabolic stress in cells dependent on mitochondrial respiration. It is especially relevant in cancer research, where tumor cells with high oxidative metabolism are targeted. The disodium salt form improves aqueous solubility and formulation stability. IACS-8803 disodium is used in oncology and metabolic disease studies to investigate mitochondrial function, energy metabolism, and the development of therapeutics aimed at disrupting tumor bioenergetics.

Reference

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.
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