IACS-13909（Cat No.:I029016）is a selective inhibitor of signal transducer and activator of transcription 3 (STAT3), a transcription factor frequently dysregulated in cancer and inflammatory diseases. By blocking STAT3 phosphorylation and its subsequent nuclear translocation, IACS-13909 disrupts the transcription of genes involved in cell survival, proliferation, and immune evasion. It has demonstrated potent anti-tumor activity in preclinical models of hematologic and solid tumors, particularly those with constitutive STAT3 activation. IACS-13909 holds promise as a targeted therapeutic for malignancies driven by aberrant STAT3 signaling, offering potential for improved treatment outcomes with reduced systemic toxicity.