• CAT Number: I001045
  • CAS Number: 1260907-17-2
  • Molecular Formula: C₂₂H₂₂ClN₅O₂
  • Molecular Weight: 423.9
  • Purity: ≥95%
Inquiry Now

I-BET762 (CAT: I001045) is a potent and selective inhibitor of the bromodomain and extra-terminal (BET) family of proteins, which play a key role in the regulation of gene expression. It binds to the bromodomains of BET proteins, preventing their interaction with acetylated lysines on histones and leading to the downregulation of genes involved in cancer cell growth and survival. I-BET762 has shown promise as an anti-cancer therapeutic, with preclinical studies demonstrating efficacy against a range of hematological and solid tumors. Clinical trials have also been conducted in patients with advanced solid tumors, although further research is needed to fully evaluate its potential as a cancer treatment.

Catalog Number I001045
CAS Number 1260907-17-2
Molecular Formula


Purity 95%
Target Bromodomain
Solubility 10 mM in DMSO
Storage Store at -20C
IC50 ~35 nM
InChI nChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1

<p style=”/line-height:25px/”>
<br />
[1]. Nicodeme, E., et al., Suppression of inflammation by a synthetic histone mimic. Nature, 2010. 468(7327): p. 1119-23.<br />
[2]. Bandukwala, H.S., et al., Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A, 2012. 109(36): p. 14532-7.</p>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!