I-BET567

• CAT Number: I045210
• CAS Number: 1887237-54-8
• Molecular Formula: C17H18ClN5O2
• Molecular Weight: 359.81
• Purity: ≥95%
• Synonyms: (2S,4R)-1-acetyl-4-[(5-chloropyrimidin-2-yl)amino]-2-methyl-3,4-dihydro-2H-quinoline-6-carboxamide
• InChI: InChI=1S/C17H18ClN5O2/c1-9-5-14(22-17-20-7-12(18)8-21-17)13-6-11(16(19)25)3-4-15(13)23(9)10(2)24/h3-4,6-9,14H,5H2,1-2H3,(H2,19,25)(H,20,21,22)/t9-,14+/m0/s1
• InChIKey: KNBYFXZNSOENGW-LKFCYVNXSA-N
• SMILES: C[C@H]1C[C@H](C2=C(N1C(=O)C)C=CC(=C2)C(=O)N)NC3=NC=C(C=N3)Cl

I-BET567（Cat No.:I045210）is a potent, selective inhibitor of bromodomain and extra-terminal (BET) family proteins, including BRD2, BRD3, and BRD4, which regulate gene transcription by recognizing acetylated lysine residues on histones. By blocking BET–chromatin interactions, I-BET567 suppresses expression of oncogenes such as MYC, leading to reduced tumor cell proliferation and survival. It has demonstrated strong activity in preclinical models of hematologic malignancies and solid tumors. I-BET567 is a valuable research tool for studying epigenetic regulation, transcriptional control, and cancer biology, with therapeutic potential in oncology and inflammation-driven diseases.