For research use only. Not for therapeutic Use.
Hydroxy ziprasidone(CAT: R032581) is a major active metabolite of the atypical antipsychotic ziprasidone, generated primarily through hepatic metabolism. It retains pharmacological activity at dopamine and serotonin receptors, contributing to the overall therapeutic profile of the parent drug. Hydroxy ziprasidone displays antagonism at dopamine D₂ receptors and serotonin 5-HT₂A receptors, while also modulating 5-HT₁A and other serotonergic subtypes, supporting its role in antipsychotic efficacy. This metabolite is widely studied in pharmacokinetics, metabolism, and receptor binding assays to better understand ziprasidone’s clinical activity, safety, and variability in patient response. Hydroxy ziprasidone is a useful reference compound for neuropharmacology and drug metabolism research.
| CAS Number | 884305-08-2 |
| Synonyms | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1-hydroxyethyl]-6-chloro-1,3-dihydroindol-2-one |
| Molecular Formula | C21H21ClN4O2S |
| Purity | ≥95% |
| IUPAC Name | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1-hydroxyethyl]-6-chloro-1,3-dihydroindol-2-one |
| InChI | InChI=1S/C21H21ClN4O2S/c22-16-11-17-13(10-20(28)23-17)9-15(16)18(27)12-25-5-7-26(8-6-25)21-14-3-1-2-4-19(14)29-24-21/h1-4,9,11,18,27H,5-8,10,12H2,(H,23,28) |
| InChIKey | IYNREZQRIITXHB-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC(C2=C(C=C3C(=C2)CC(=O)N3)Cl)O)C4=NSC5=CC=CC=C54 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
