Hydroxy Pioglitazone (M-IV)

• CAT Number: R002805
• CAS Number: 146062-44-4
• Molecular Formula: C19H20N2O4S
• Molecular Weight: 372.44
• Purity: ≥95%
• Synonyms: 5-[[4-[2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione
• Target: Vitamin D Related/Nuclear Receptor
• Storage: -80°C
• IUPAC Name: 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)
• InChIKey: OXVFDZYQLGRLCD-UHFFFAOYSA-N
• SMILES: CC(C1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)O

Hydroxy Pioglitazone (M-IV)(CAT: R002805) is a major active metabolite of the antidiabetic drug pioglitazone, belonging to the thiazolidinedione (TZD) class. Like its parent compound, M-IV functions as a selective PPARγ agonist, regulating gene expression linked to glucose uptake, lipid metabolism, and insulin sensitivity. With comparable or slightly reduced potency to pioglitazone, Hydroxy Pioglitazone is critical in pharmacokinetic and pharmacodynamic studies, enabling researchers to understand drug metabolism, bioavailability, and therapeutic efficacy. Its role in modulating metabolic pathways also supports broader research into type 2 diabetes, metabolic syndrome, and cardiovascular disease, making it an important reference standard in biomedical studies.