Hydroxy-PEG4-methyl acetate

• CAT Number: I044630
• CAS Number: 77303-64-1
• Molecular Formula: C11H22O7
• Molecular Weight: 266.29
• Purity: ≥95%
• Synonyms: methyl 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetate
• InChI: InChI=1S/C11H22O7/c1-14-11(13)10-18-9-8-17-7-6-16-5-4-15-3-2-12/h12H,2-10H2,1H3
• InChIKey: CKNALYRJLYKSLK-UHFFFAOYSA-N
• SMILES: COC(=O)COCCOCCOCCOCCO

Hydroxy-PEG4-methyl acetate（Cat No.:I044630）is a monofunctional polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a methyl acetate moiety, linked via a four-unit PEG spacer. The hydroxyl end allows further chemical modification, such as esterification or etherification, while the methyl acetate group provides temporary protection and can be hydrolyzed under mild acidic or basic conditions. The PEG4 chain enhances solubility, flexibility, and biocompatibility, making this molecule useful in surface modification, drug delivery systems, and polymer chemistry. It is particularly suited for designing functionalized materials and bioactive conjugates.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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