Hydroxy-PEG4-(CH2)2-Boc

• CAT Number: I016722
• CAS Number: 518044-32-1
• Molecular Formula: C₁₅H₃₀O₇
• Molecular Weight: 322.39
• Purity: ≥95%
• Target: PROTAC
• Storage: 2-8°C
• IUPAC Name: tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
• InChIKey: FJRDXEGYAVAMLB-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCO

Hydroxy-PEG4-(CH2)2-Boc（Cat No.:I016722） is an uncleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). It is derived from compound 191 in patent WO2004008101A2. The linker consists of a hydroxy-PEG4 spacer connected to a (CH2)2-Boc moiety. In ADCs, this linker enables the conjugation of drugs to antibodies, facilitating targeted drug delivery. As a PROTAC linker, it plays a crucial role in bridging the target protein and the E3 ligase, leading to selective protein degradation. Hydroxy-PEG4-(CH2)2-Boc offers versatility and stability in the development of novel therapeutics targeting cancer and other diseases.

Reference

[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.