2-Hydroxyflutamide is an androgen receptor antagonist potentially for the treatment of prostate cancer
| Catalog Number | R001760 |
| CAS Number | 52806-53-8 |
| Synonyms | 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Hydroxyniphtholide; Sch 16423; α,α,α-Trifluoro-2-methyl-4’-nitro-m-?lactotoluidide;? |
| Molecular Formula | C11H11F3N2O4 |
| Purity | 95% |
| Target | Androgen Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| InChI | InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17) |
| InChIKey | YPQLFJODEKMJEF-UHFFFAOYSA-N |
| SMILES | CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O |
| Reference | </br>1:A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo. Blobaum AL, Byers FW, Bridges TM, Locuson CW, Conn PJ, Lindsley CW, Daniels JS.Drug Metab Dispos. 2015 Nov;43(11):1718-26. doi: 10.1124/dmd.115.064006. Epub 2015 Aug 11. PMID: 26265743 Free PMC Article</br>2:Effects of flutamide and hydroxy-flutamide on the growth of human benign prostatic hyperplasia cells in primary culture: a preliminary report. Hallowes R, Cox S, Hayward S, Deshpande N, Towler J.Anticancer Res. 1991 Sep-Oct;11(5):1799-805. PMID: 1722658 </br>3:Plasma levels of hydroxy-flutamide in patients with prostatic cancer receiving the combined hormonal therapy: an LHRH agonist and flutamide. Bélanger A, Giasson M, Couture J, Dupont A, Cusan L, Labrie F.Prostate. 1988;12(1):79-84. PMID: 3279409 |
