For research use only. Not for therapeutic Use.
HS271 (Cat No.: I045441) is a mitochondria-targeted, near-infrared (NIR) fluorescent probe designed for optical imaging of tumor metabolism and mitochondrial membrane potential. It accumulates selectively in cancer cell mitochondria due to its lipophilic cationic structure, enabling high-contrast imaging in vivo. HS271 is photoactivatable, allowing light-induced photodynamic therapy (PDT) to induce mitochondrial damage and cell death. This dual-function probe is used in cancer research for tumor detection, image-guided therapy, and studying mitochondrial dynamics, combining diagnostic and therapeutic potential within a single molecular platform.
| CAS Number | 2410393-15-4 |
| Synonyms | N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
| Molecular Formula | C21H24F3N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H24F3N5O2/c1-20(2,31)14-11-16-13(12-29(27-16)9-8-28(3)4)10-17(14)26-19(30)15-6-5-7-18(25-15)21(22,23)24/h5-7,10-12,31H,8-9H2,1-4H3,(H,26,30) |
| InChIKey | QAOWCAZEVIIQTF-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)CCN(C)C)O |
| Reference | [1]. Wenqiang Zhai, et al. Discovery and optimization of a potent and selective indazolamine series of IRAK4 inhibitors. Bioorg Med Chem Lett. 2020 Nov 24;31:127686. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
