HS-1371

• CAT Number: I019595
• CAS Number: 2158197-70-5
• Molecular Formula: C₂₄H₂₄N₄O
• Molecular Weight: 384.47
• Purity: ≥95%
• Storage: Room temperature
• IUPAC Name: 4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline
• InChI: InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
• InChIKey: VPVLPCIBKVWFDT-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5

HS-1371 (Cat No.: I019595) is a potent inhibitor of RIP3 kinase, a key enzyme involved in programmed cell death pathways. It exhibits impressive inhibitory activity with an IC50 of 20.8 nM. HS-1371 achieves its inhibitory effect by binding to the ATP-binding domain of RIP3, preventing ATP binding and subsequently inhibiting the kinase activity of RIP3 in vitro. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125.