For research use only. Not for therapeutic Use.
HPK1-IN-7（Cat No.:I044570）is a potent and selective small-molecule inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), a negative regulator of T cell receptor (TCR) signaling. By inhibiting HPK1, HPK1-IN-7 enhances T cell activation, cytokine production, and immune responses, making it a promising candidate for cancer immunotherapy. The compound has demonstrated robust activity in preclinical models, supporting its role in overcoming immune suppression within the tumor microenvironment. HPK1-IN-7 is valuable for studying immune checkpoint regulation and developing combination therapies aimed at boosting antitumor immunity through targeted modulation of T cell signaling pathways.
| CAS Number | 2320462-65-3 |
| Synonyms | 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino]-3,3-dimethyl-2-benzofuran-1-one |
| Molecular Formula | C24H22N6O4 |
| Purity | ≥95% |
| IUPAC Name | 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino]-3,3-dimethyl-2-benzofuran-1-one |
| InChI | InChI=1S/C24H22N6O4/c1-24(2)18-10-15(8-9-16(18)22(32)34-24)27-23-25-11-17(21-30-26-13-33-21)20(29-23)28-19(12-31)14-6-4-3-5-7-14/h3-11,13,19,31H,12H2,1-2H3,(H2,25,27,28,29)/t19-/m1/s1 |
| InChIKey | RVSSNRBUPQUIEG-LJQANCHMSA-N |
| SMILES | CC1(C2=C(C=CC(=C2)NC3=NC=C(C(=N3)N[C@H](CO)C4=CC=CC=C4)C5=NN=CO5)C(=O)O1)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
