For research use only. Not for therapeutic Use.
HPK1-IN-4（Cat No.:I044614）is a potent small-molecule inhibitor targeting Hematopoietic Progenitor Kinase 1 (HPK1), a negative regulator of T-cell receptor signaling. By selectively blocking HPK1 activity, HPK1-IN-4 enhances T-cell activation and cytokine production, making it a promising immunomodulatory agent for cancer immunotherapy. Its optimized pharmacokinetic profile ensures effective cellular uptake and sustained activity. HPK1-IN-4 is widely used in preclinical research to explore T-cell-mediated anti-tumor responses, immune checkpoint synergy, and the development of next-generation immunotherapies targeting intracellular signaling pathways involved in immune suppression and tumor evasion.
| CAS Number | 2739844-28-9 |
| Synonyms | 4-[2-(hydroxymethyl)anilino]-2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]pyrimidine-5-carboxamide |
| Molecular Formula | C23H26N6O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[2-(hydroxymethyl)anilino]-2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]pyrimidine-5-carboxamide |
| InChI | InChI=1S/C23H26N6O3/c1-29-8-7-14-10-20(32-2)19(9-16(14)12-29)27-23-25-11-17(21(24)31)22(28-23)26-18-6-4-3-5-15(18)13-30/h3-6,9-11,30H,7-8,12-13H2,1-2H3,(H2,24,31)(H2,25,26,27,28) |
| InChIKey | BNZFLUIBCNIAJW-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C1)NC3=NC=C(C(=N3)NC4=CC=CC=C4CO)C(=O)N)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
