For research use only. Not for therapeutic Use.
HPK1-IN-3（Cat No.:I044615）is a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), an intracellular kinase that negatively regulates T-cell receptor signaling. By blocking HPK1 activity, HPK1-IN-3 enhances T-cell activation, proliferation, and cytokine release, making it a valuable candidate in cancer immunotherapy research. This compound is designed for high potency, selectivity, and favorable pharmacokinetics, supporting its use in both in vitro and in vivo studies. HPK1-IN-3 is instrumental in evaluating immune enhancement strategies, particularly in combination with immune checkpoint inhibitors, for improving antitumor immune responses in preclinical models.
| CAS Number | 2739844-34-7 |
| Synonyms | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]pyrimidine-5-carboxamide |
| Molecular Formula | C23H22F4N6O2 |
| Purity | ≥95% |
| IUPAC Name | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]pyrimidine-5-carboxamide |
| InChI | InChI=1S/C23H22F4N6O2/c1-33-7-6-12-9-18(35-2)17(8-13(12)11-33)30-22-29-10-14(20(28)34)21(32-22)31-19-15(23(25,26)27)4-3-5-16(19)24/h3-5,8-10H,6-7,11H2,1-2H3,(H2,28,34)(H2,29,30,31,32) |
| InChIKey | RZLXOEIALAVGKH-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C1)NC3=NC=C(C(=N3)NC4=C(C=CC=C4F)C(F)(F)F)C(=O)N)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
