For research use only. Not for therapeutic Use.
HPK1-IN-19（Cat No.:I045179）is a potent, selective inhibitor of hematopoietic progenitor kinase 1 (HPK1), a negative regulator of T cell receptor (TCR) signaling. By blocking HPK1 activity, HPK1-IN-19 enhances T cell activation, cytokine production, and anti-tumor immune responses. It shows promise in cancer immunotherapy by boosting immune cell function and overcoming tumor-induced immunosuppression. This compound is a valuable research tool for investigating HPK1-mediated immune regulation and for developing novel immuno-oncology strategies aimed at improving checkpoint inhibitor efficacy and promoting durable anti-cancer immunity in preclinical and translational studies.
| CAS Number | 2227609-33-6 |
| Synonyms | 4-N-(2-dimethylphosphorylphenyl)-2-N-(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)-5-(1-methylpyrazol-4-yl)pyrimidine-2,4-diamine |
| Molecular Formula | C27H32N7O2P |
| Purity | ≥95% |
| IUPAC Name | 4-N-(2-dimethylphosphorylphenyl)-2-N-(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)-5-(1-methylpyrazol-4-yl)pyrimidine-2,4-diamine |
| InChI | InChI=1S/C27H32N7O2P/c1-33-11-10-18-13-24(36-3)23(12-19(18)16-33)31-27-28-15-21(20-14-29-34(2)17-20)26(32-27)30-22-8-6-7-9-25(22)37(4,5)35/h6-9,12-15,17H,10-11,16H2,1-5H3,(H2,28,30,31,32) |
| InChIKey | AZENVIBXSMLBQC-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C1)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)C5=CN(N=C5)C)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
