For research use only. Not for therapeutic Use.
HPA-12(CAT: I028871) is a synthetic ceramide analog and potent inhibitor of ceramide trafficking, particularly known for its ability to block the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus. This inhibition disrupts sphingolipid metabolism and affects downstream signaling pathways related to cell growth, apoptosis, and lipid homeostasis. HPA-12 is widely used in cell biology and lipidomics research to study sphingolipid biosynthesis, membrane dynamics, and metabolic regulation. It also serves as a tool compound in investigating diseases involving ceramide dysregulation, including cancer, neurodegeneration, and metabolic disorders.
| CAS Number | 383418-30-2 |
| Synonyms | N-[(2R,4S)-1,4-dihydroxy-4-phenylbutan-2-yl]dodecanamide |
| Molecular Formula | C22H37NO3 |
| Purity | ≥95% |
| IUPAC Name | N-[(2R,4S)-1,4-dihydroxy-4-phenylbutan-2-yl]dodecanamide |
| InChI | InChI=1S/C22H37NO3/c1-2-3-4-5-6-7-8-9-13-16-22(26)23-20(18-24)17-21(25)19-14-11-10-12-15-19/h10-12,14-15,20-21,24-25H,2-9,13,16-18H2,1H3,(H,23,26)/t20-,21+/m1/s1 |
| InChIKey | YCAKBKAOFSILDC-RTWAWAEBSA-N |
| SMILES | CCCCCCCCCCCC(=O)NC(CC(C1=CC=CC=C1)O)CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
