For research use only. Not for therapeutic Use.
Honokiol DCA（Cat No.:I028864）is a synthetic derivative combining honokiol, a natural biphenolic compound from Magnolia species, with dichloroacetate (DCA) to enhance anticancer activity. Honokiol possesses anti-inflammatory, antioxidant, and anticancer properties, while DCA targets cancer cell metabolism by inhibiting pyruvate dehydrogenase kinase (PDK), shifting metabolism from glycolysis to mitochondrial oxidation. The conjugate Honokiol DCA synergistically induces apoptosis, reduces tumor growth, and disrupts mitochondrial function more effectively than either compound alone. It is a promising research tool for studying cancer metabolism, mitochondrial regulation, and therapeutic strategies against resistant cancer types.
| CAS Number | 1620160-42-0 |
| Synonyms | [4-[2-(2,2-dichloroacetyl)oxy-5-prop-2-enylphenyl]-2-prop-2-enylphenyl] 2,2-dichloroacetate |
| Molecular Formula | C22H18Cl4O4 |
| Purity | ≥95% |
| IUPAC Name | [4-[2-(2,2-dichloroacetyl)oxy-5-prop-2-enylphenyl]-2-prop-2-enylphenyl] 2,2-dichloroacetate |
| InChI | InChI=1S/C22H18Cl4O4/c1-3-5-13-7-9-18(30-22(28)20(25)26)16(11-13)14-8-10-17(15(12-14)6-4-2)29-21(27)19(23)24/h3-4,7-12,19-20H,1-2,5-6H2 |
| InChIKey | KSJLHVAHFGNFFU-UHFFFAOYSA-N |
| SMILES | C=CCC1=CC(=C(C=C1)OC(=O)C(Cl)Cl)C2=CC(=C(C=C2)OC(=O)C(Cl)Cl)CC=C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
