Homopropargylglycine

• CAT Number: I042515
• CAS Number: 215160-72-8
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14
• Purity: ≥95%
• Synonyms: 2-aminohex-5-ynoic acid
• InChI: InChI=1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
• InChIKey: SCGJGNWMYSYORS-UHFFFAOYSA-N
• SMILES: C#CCCC(C(=O)O)N

Homopropargylglycine (Cat No.: I042515) is a non-natural amino acid analog of methionine featuring a terminal alkyne group, making it ideal for bioorthogonal labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC), also known as “click chemistry.” HPG can be incorporated into newly synthesized proteins in place of methionine during translation, enabling selective tagging and tracking in proteomic and imaging studies. It is widely used in cell biology, protein engineering, and metabolic labeling to investigate protein synthesis, turnover, and localization in a non-invasive, high-resolution manner.

Reference

[1]. Tivendale ND, Millar AH, et al. In vivo homopropargylglycine incorporation enables sampling, isolation and characterization of nascent proteins from Arabidopsis thaliana. Plant J. 2021 Aug;107(4):1260-1276.
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