Homopiperazine

• CAT Number: R041930
• CAS Number: 505-66-8
• Molecular Formula: C5H12N2
• Molecular Weight: 100.16
• Purity: ≥95%
• Synonyms: Hexahydro-1H-1,4-diazepine; 1,4-Diazacycloheptane; Hexahydro-1,4-diazepine; Hexahydro-1H-1,4-diazepine; Homopiperazine; Perhydro-1,4-diazepine; Trimethyleneethylenediamine
• Storage: -20°C
• IUPAC Name: 1,4-diazepane
• InChI: InChI=1S/C5H12N2/c1-2-6-4-5-7-3-1/h6-7H,1-5H2
• InChIKey: FQUYSHZXSKYCSY-UHFFFAOYSA-N
• SMILES: C1CNCCNC1

Homopiperazine（Cat No.:R041930）is a saturated nitrogen-containing heterocycle consisting of a seven-membered ring with two nitrogen atoms at opposite positions (1,4-diaza-cycloheptane). It serves as a versatile building block in medicinal chemistry, polymer science, and organic synthesis. Compared to piperazine, the additional methylene group in homopiperazine introduces greater conformational flexibility and alters pharmacokinetic profiles when incorporated into bioactive molecules. Its basic nitrogen atoms enable salt formation, nucleophilic substitution, and functionalization for drug design, particularly in central nervous system (CNS) and antimicrobial research. Homopiperazine is also useful in preparing ligands and macrocyclic compounds.