HOIPIN-8

• CAT Number: I028846
• Molecular Formula: C23H15F2N4NaO3
• Molecular Weight: 456.38
• Purity: ≥95%
• Synonyms: sodium;2-[(E)-3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoate
• InChI: InChI=1S/C23H16F2N4O3.Na/c1-29-12-17(11-28-29)13-2-4-18(23(31)32)14(6-13)3-5-21(30)22-19(24)7-15(8-20(22)25)16-9-26-27-10-16;/h2-12H,1H3,(H,26,27)(H,31,32);/q;+1/p-1/b5-3+
• InChIKey: DLJPWYFLGYVMKV-WGCWOXMQSA-M
• SMILES: CN1C=C(C=N1)C2=CC(=C(C=C2)C(=O)[O-])/C=C/C(=O)C3=C(C=C(C=C3F)C4=CNN=C4)F.[Na+]

HOIPIN-8（Cat No.:I028846）is a selective small-molecule inhibitor of HOIP (HOIL-1-interacting protein), the catalytic subunit of the linear ubiquitin chain assembly complex (LUBAC). By blocking linear ubiquitination, HOIPIN-8 suppresses activation of the NF-κB signaling pathway, a key regulator of inflammation, immune responses, and cell survival. This compound has shown promise in preclinical studies for modulating autoimmune and inflammatory diseases, as well as certain cancers driven by aberrant NF-κB activation. HOIPIN-8 is widely used in chemical biology research to dissect ubiquitin signaling and explore therapeutic strategies targeting inflammatory pathways.