HOIPIN-1

• CAT Number: I028845
• Molecular Formula: C17H13NaO4
• Molecular Weight: 304.28
• Purity: ≥95%

HOIPIN-1 is (Cat No.: I028845) a small-molecule inhibitor of HOIP (HOIL-1-interacting protein), the catalytic subunit of the linear ubiquitin chain assembly complex (LUBAC). By selectively blocking linear (M1-linked) ubiquitination, HOIPIN-1 suppresses NF-κB signaling and modulates innate and adaptive immune responses. Researchers use HOIPIN-1 to investigate inflammation, immune regulation, and cancer pathways dependent on ubiquitin signaling. Its specificity provides a powerful tool for dissecting LUBAC function, enabling the study of ubiquitin-mediated signaling in autoimmune disease, chronic inflammation, and tumor biology.

Reference

[1]. Ken Katsuya, et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System. SLAS Discov. 2018 Dec;23(10):1018-1029
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[2]. Ken Katsuya, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706.
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